Bismuth (III) Triflate Catalyzed Multicomponent Synthesis of 2,4,5-Trisubstituted Imidazoles

Substituted imidazoles are of interest because their useful biological activities. While several methods have been developed for the synthesis such compounds, some reported utilize corrosive or toxic catalysts. We report a bismuth (III) triflate catalyzed multicomponent 2,4,5-trisubstituted imidazoles. Bismuth compounds attractive from green chemistry perspective they remarkably non-toxic and non-corrosive. Multicomponent syntheses save time generate less waste.